Raspberry Ketone Research Studies

lab testingA curated index of scientific research which has been performed on raspberry ketone, and several articles written and reviewed by medical professionals.

Last updated: October 8, 2014

Scientific Studies and Abstracts

Anti-obese action of raspberry ketone
Life Sciences, May 27, 2005
http://www.ncbi.nlm.nih.gov/pubmed/15862604

Study to determine if Raspberry Ketone ("RK") improves lipid ("fat") metabolism and prevents obesity in rats. The study concluded that RK did indeed prevent and improve obesity and fatty liver in the test subjects.

Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes
Planta Medica, April 27, 2010
http://www.ncbi.nlm.nih.gov/pubmed/20425690

Concluded that RK's biological activities alter the lipid metabolism in certain types of adipocytes (aka "fat cells") - increasing fatty acid oxidation and suppressing the accumulation of lipids .

Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis
Journal of Medicinal Food. May 15, 2012
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338106/

Non-alcoholic steatohepatitis is fatty liver disease caused by a high-fat diet. This study, also done on rats, concluded that RK can decrease lipid levels in blood and in liver tissue, reduce inflammation in the liver and protect liver cells. The full study writeup is available online, and includes several graphs and charts showing the results.

Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women
Journal of the International Society of Sports Nutrition, April 19, 2013
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639826/

This study, a randomized, placebo-controlled, double-blind study on 70 obese but otherwise healthy human subjects, sought to determine the safety and effectiveness of a multi-ingredient supplement containing raspberry ketone as the primary ingredient (along with caffeine, capsaicin, garlic, ginger and bitter orange extract), taken in conjunction with an eight-week diet and exercise program.

The study concluded that the product was safe and effective. While both placebo and non-placebo groups lost weight and body fat, the group given the supplement showed additional improvements in body composition and in waist and hip measurements.

To date, this is the only study we could find on raspberry ketone as a weight-loss supplement which was conducted on humans.

Raspberry ketone promotes the differentiation of C3H10T1/2 stem cells into osteoblasts.
Journal of Medicinal Food, March, 2014
http://www.ncbi.nlm.nih.gov/pubmed/24404978

Stem cell research indicating that raspberry ketone appears to promote bone formation. Much more research is needed, but it is possible that it may someday play a role in the treatment of osteoporosis.

Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans
Growth hormone and IGF Research, August 18, 2008
http://www.ncbi.nlm.nih.gov/pubmed/18321745

A study examining the effects of the topical (on the skin) application of RK in humans. When applied to the scalp, RK promoted hair growth in 50.0% of humans with alopecia (hair loss, baldness) after 5 months of application. It also resulted in increased facial skin elasticity after 2 weeks of use in a small group of women.

The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits
Xenobiotica, April 12, 1982
http://www.ncbi.nlm.nih.gov/pubmed/7113261

This study showed how RK was metabolized in the test animals.

 

Further Reading

Articles and blog posts written and/or reviewed by doctors, nurses and naturopaths. While they may be influenced by the opinions of the author, these articles are not sponsored by or written to promote any particular brand or product so they present a relatively unbiased look at the pros and cons of this supplement.

Doctor Oz: Raspberry Ketone - What Science Says

April 19, 2012
Companion article to the TV show which kicked off all the buzz about raspberry ketone.

You can watch the video from the Dr. Oz Show here.

 

Clinical Advisor: Raspberry ketones May Aid In Weight Loss

July 2, 2013
A look at the evidence surrounding raspberry ketones as a diet supplement by Sherril Sego, FNP-C, DNP - a nursing school instructor, and staff clinician at the VA Hospital in Kansas City, Mo.

 

WebMD: Raspberry Ketone: Uses, Health Benefits and Risks

October 24, 2012
Overview of raspberry ketones as a diet supplement from WebMD. ,

 

Alternative Holistic Health Answers: Raspberry Ketones - What is the evidence beyond Dr. Oz?

March 12, 2012
Commentary by blogger and naturopathic doctor Christopher Maloney, with abstracts from several research studies.

 

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